Obtaining Deep Mechanistic Insights from and into the Human System
Sponsored by the AAI Clinical Immunology Committee
- Jordan S. Orange, Columbia Univ. Med. Ctr., AAI Clinical Immunology Committee Chair
- Veena Taneja, Mayo Clin.
- Megan A. Cooper, Washington Univ. Sch. of Med. in St. Louis, Immune dysregulation with STAT3 gain-of-function
- Janet Chou, Harvard Med. Sch., Novel immunodeficiencies from the ICID network
- Mark S. Anderson, Univ. of California, San Francisco, Central immune tolerance and human autoimmunity
- Helen Su, NIAID/NIH, Elucidating molecular mechanisms of a novel inherited immunodeficiency-immunodysregulation disorder
The study of human disease has always provided the opportunity to derive unconventional insights into immunology. Current genomic technologies and cutting-edge biological approaches have not only made these opportunities more accessible, but they are being brought to bear with greater frequency and impact. Aberrant human immunity owing to inherent genetic influence can result in immunodeficiency, immunodysregulation, autoimmunity, autoinflammation or blends of these clinical expressions. The faculty of this session have made seminal contributions understanding how aberrant immunity causes clinical disease while providing profound mechanistic insights into how the human immune system works.